The human body has a powerful immune system, and one of its white blood cells called a T-cell is like a solider capable of attacking and killing abnormal cancerous cells. However, in cancer patients, these T cells are compromised, either fail to target or recognize cancerous cells, or are too few in number to lead an strong attack. Aurora’s revolutionary CAR T Cell Therapy change a cancer patient’s own weak T cells into “bionic” killing machines —a highly targeted army that can kill cancer. A cancer patient’s T cells are removed from a blood draw, genetically engineered in a laboratory, expanded to almost a billion CAR T cells, and re-infused back into the patient where they are better able to kill cancer.
Aurora’s CAR T Cells have been shown to kill multiple types of solid tumors in pre-clinical animal studies, and in completed human trials. In two completed Phase I/II clinical trials in Sarcoma and Glioblastoma, our revolutionary CAR T Cell therapy AU101 and AU105 showed it can be safe, produce tumor killing and increase survival.